A Randomized, Double-Blind, Placebo-Controlled Evaluation of Coffea Arabica Seed Extract for Cognitive and Mood Impacts in Healthy Adults Original Research
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Keywords
chlorogenic acid, polyphenols, cognition, mood, coffee
Abstract
Introduction: NeuroRush™ is a dietary ingredient comprised of the seed extract of the Coffea arabica. It is rich in polyphenols and chlorogenic acid (CGA). CGAs are linked to positive health impacts and are believed to support cognitive function. This study aimed to determine if a dietary supplement made of Coffee arabica seed extract would affect cognitive function and mood states in healthy adults.
Methods: In a randomized, double-blind, placebo-controlled crossover trial, 19 healthy adults consumed either NeuroRush™ (150 mg coffee seed extract) or placebo (150 mg of maltodextrin). Participants completed cognitive tests (Go/No-Go, Stroop, and N-Back), subjective mood assessments, and safety monitoring at baseline and 1-, 2-, and 3 hours post-ingestion.
Results: Significant main effects of time were observed for cognitive performance across tasks, including improvements in Stroop total score (p = 0.016), Stroop reaction time (p = 0.013), and N-Back correct responses (p = 0.010). The NeuroRush™ group exhibited enhanced N-Back accuracy (p = 0.008, d = 0.85) and a trend toward faster overall Go reaction times. Self-reported well-being was significantly greater in the NeuroRush™ group at 3 hours compared to placebo (p = 0.047, d = 0.64).
Conclusions: Acute ingestion of NeuroRush™ may mildly enhance cognitive performance, particularly working memory and processing efficiency, and improve well-being in healthy adults. NeuroRush™ was well-tolerated and was safe within the confines of the study design. Longer-term research is warranted to determine if the enhanced cognitive impacts and mood states remain over time.
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