Acute Bout of Resistance Training Reduces Glucagon-like Peptide 1 Concentration in Females
Main Article Content
Keywords
Resistance training, Hormones, Females
Abstract
Introduction: Resistance training (RT), is a common and recommended strategy for improving muscle mass and function that may modify appetite biomarkers. Glucagon- like peptide-1 (GLP-1) is a rapid acting appetite control hormone. The purpose of this study was to determine if RT effects GLP-1 in females independent of an exercise promoted calorie deficit.
Methods: Two randomized experimental beverages with differing calories were given prior to two RT days: 1) matched calories for RT (MC) and 2) no calories (NC). RT; 3 sets, 10 repetitions, 8 standard exercises at 70% 1-RM. Fasted blood was collected pre-beverage (PRE), 15-minutes post-beverage (POST), 5P, 15P, and 30P-minutes post-RT.
Results: Six females (age 21.8 ± 2.6 yrs) completed the study. Differences from PRE to POST, 5p, 15P, 30P were measured with ANOVA, and main effects analyzed with Cohen’s d effect size (d). NC promoted a significant reduction in GLP-1 at 15P, 30P RT (GLP-1 PRE 3.25 ±2.5, 15P 2.42 ±2.6, 30P2.46 ±2.1 ng/dL, p ≤ 0.05). There was no significant difference in GLP-1 in the matched calorie treatment (MC) at any time point in the study (PRE to POST, 5P, 15P & 30P).
Conclusions: Our research suggests that RT does not activate GLP-1 secretion followinganacuteboutofexerciseindependentofcaloricexpenditure. Rather,RT performed without pre-exercise calorie consumption reduced GLP-1 in physically active females.
References
2. Broom DR, Batterham RL, King JA, Stensel DJ. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol. 2009;296(1):R29-35. doi:10.1152/ajpregu.90706.2008
3. Harrington DM, Martin CK, Ravussin E, Katzmarzyk PT. Activity related energy expenditure, appetite and energy intake. Potential implications for weight management. Appetite. 2013;67:1-7. doi:10.1016/j.appet.2013.03.005
4. King JA, Wasse LK, Stensel DJ. Acute exercise increases feeding latency in healthy normal
weight young males but
doi:10.1016/j.appet.2012.10.018
5. Deighton K, Barry R, Connon CE, Stensel DJ. Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise. Eur J Appl Physiol. 2012;113(5):1147-1156. doi:10.1007/s00421-012-2535-1
6. Ahima RS, Antwi DA. Brain regulation of appetite and satiety. Endocrinol Metab Clin North Am. 2008;37(4):811-823. doi:10.1016/j.ecl.2008.08.005
7. Baggio LL, Drucker DJ. Biology of Incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131- 2157. doi:10.1053/j.gastro.2007.03.054
8. Hellström PM. GLP-1 playing the role of a gut regulatory compound. Acta Physiol Oxf Engl. 2011;201(1):151-156. doi:10.1111/j.1748-1716.2010.02150.x
9. Association NS and C. Essentials of Strength Training and Conditioning - 3rd Edition. 3 edition. Human Kinetics; 2008.
10. American College of Sports Medicine. ACSM’s Guidelines for Exercise Testing and Prescription. 9th ed. Lippincott Williams & Wilkins; 2013.
11. Cohen J. Statistical Power Analysis for the Behavioral Science. 2nd ed. Routledge; 1988.
12. Cheng MH-Y, Bushnell D, Cannon DT, Kern M. Appetite regulation via exercise prior or
subsequent to high-fat meal consumption. Appetite. 2009;52(1):193-198. doi:10.1016/j.appet.2008.09.015 13. Martins C, Morgan LM, Bloom SR, Robertson MD. Effects of exercise on gut peptides, energy intake and appetite. J Endocrinol. 2007;193(2):251-258. doi:10.1677/JOE-06-0030
14. Hagobian TA, Braun B. Physical activity and hormonal regulation of appetite: sex differences and weight control. Exerc Sport Sci Rev. 2010;38(1):25-30. doi:10.1097/JES.0b013e3181c5cd98
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright, 2025 by the authors. This work is licensed under the Creative Commons Attribution 4.0 International License.