Main Article Content
body composition, gut, microbiome, prebiotic, fat mass, obesity, abdominal fat
Introduction: There is evidence in rodents as well as obese adults that probiotic supplementation can promote a decrease in fat mass. For instance, Bifidobacterium animalis ssp. lactis 420 (B420) has been shown to decrease abdominal fat mass. Therefore, our laboratory determined the effects of probiotic supplementation on body composition in a group of active men and women in a double-blind, placebo-controlled two- arm investigation.
Methods: Twenty subjects participated in this investigation (6 male, 14 female). All were actively participating in aerobic and/or resistance training for a period of at least one year. Subjects were randomly assigned to a group that received either a placebo (maltodextrin) or an encapsulated probiotic (one capsule) containing 5 billion Bifidobacterium BR03 and 5 billion Streptococcus thermophilus FP4 (Probiotical, Novara, Italy). Subjects consumed one capsule daily during the 6-week treatment period. Furthermore, subjects were instructed to not alter their diet or training regimen during this time. Body composition was assessed via dual-energy x-ray absorptiometry (DXA) (Hologic Horizon W, Danbury CT USA). Data are presented as the mean ± SD. An ANOVA was used to assess differences between groups.
Results: The physical characteristics of the placebo and probiotic groups were as follows: Placebo – Age 25±4 years, Height 168±7 centimeters; Probiotic – Age 30±8 years, Height 166±8 centimeters. Six weeks of probiotic supplementation had no effect (p > 0.05 for all) on body weight, lean body mass, fat mass, bone mineral content, body fat percentage or trunk fat mass.
Conclusions: Six weeks of daily supplementation with a probiotic containing 5 billion Bifidobacterium BR03 and 5 billion Streptococcus thermophilus FP4 in active men and women has no effect on body composition.
2. Mach N, Fuster-Botella D. Endurance exercise and gut microbiota: A review. J Sport Health Sci. 2017;6(2):179-197.
3. Jäger R, Purpura M, Stone J, et al. Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise. Nutrients. 2016;8(12):642.
4. Peake JM, Neubauer O, Della Gatta PA, Nosaka K. Muscle damage and inflammation during recovery from exercise. J Appl Physiol. 2017;122(3):559-570.
5. Mekkes MC, Weenen TC, Brummer RJ, Claassen E. The development of probiotic treatment in obesity: a review. Benef Microbes. 2014;5(1):19-28.
6. Minami J-I, Kondo S, Yanagisawa N, et al. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. J Nutr Sci. 2015;4.
7. Kondo S, Xiao J-Z, Satoh T, et al. Antiobesity Effects ofBifidobacterium breveStrain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity. Biosci Biotechnol Biochem. 2010;74(8):1656-1661.
8. Yin Y-N. Effects of fourBifidobacteriaon obesity in high-fat diet induced rats. World J Gastroenterol. 2010;16(27):3394.
9. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2008;457(7228):480-484.
10. Kristensen NB, Bryrup T, Allin KH, Nielsen T, Hansen TH, Pedersen O. Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials. Genome Med. 2016;8(1):52.
11. McFarland LV. Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review. BMJ Open. 2014;4(8):e005047-e005047.
12. Del Piano M, Carmagnola S, Andorno S, et al. Evaluation of the Intestinal Colonization by Microencapsulated Probiotic Bacteria in Comparison With the Same Uncoated Strains. J Clin Gastroenterol. 2010;44:S42-S46.